No.140
Palladium(0) Catalyst
| B3161 | Bis(tri-tert-butylphosphine)palladium(0) (1) |
250mg |
1 is a palladium complex having tri-tert-butylphosphine as the ligand. It is used in various C-C bond forming reactions. Dai and Fu have been reported to use 1 in Negishi coupling with good results.1) According to their report, they succeeded in achieving high yields for tetra-ortho-substituted biphenyls. In addition, Iizuka and Kondo have succeeded in obtaining α-ketoamide 2 in high yields from carbon monoxide, an iodobenzene derivative, and a secondary amine at room temperature in the presence of DBU and 1. α-ketoamide is a convenient intermediate that can be used in the synthesis of α-amino acids and α-hydroxycarboxylic acids.
References
1) The Pd-catalyzed coupling reactions
C. Dai, G. C. Fu, J. Am. Chem. Soc. 2001, 123, 2719[DOI].
2) Pd-catalyzed double carbonylation of aryl iodides
M. Iizuka, Y. Kondo, Chem. Commun. 2006, 1739[DOI].
C. Dai, G. C. Fu, J. Am. Chem. Soc. 2001, 123, 2719[DOI].
2) Pd-catalyzed double carbonylation of aryl iodides
M. Iizuka, Y. Kondo, Chem. Commun. 2006, 1739[DOI].
The prices are subject to change without notice. Please confirm
the newest price by our online catalog before placing an order.
fjkosk0000002jad
