No.134
Synthesis of Optically Active α-Arylglycine Derivatives
| D3259 | (5S)-5,6-Dihydro-6,6-dimethyl-5-phenyl-2H-1,4-oxazin-2-one |
1g |
Iminolactone 1 is stereoselectively added to various phenols, anilines and arylboronic acids to give an optically active morpholine derivative, like 2. The compound 2 is then subjected to ring-opening, protection and de-protection to give optically active alpha-arylglycine derivative, like 3.
References
Synthesis of optically active α-arylglycine derivatives
S. Tohma, K. Rikimaru, A. Endo, K. Shimamoto, T. Kan, T. Fukuyama, Synthesis, 2004, 909.
S. Tohma, K. Rikimaru, A. Endo, K. Shimamoto, T. Kan, T. Fukuyama, Synthesis, 2004, 909.
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