Combinatorial chemistry is a technique in which a number of compounds are simultaneously synthesized and has received much focus in the development of drugs. Of the array of products produced, which are called "libraries", those with the desired functions and activity, are easily identified and isolated. Solid-phase syntheses are widely used.
In the solid-phase syntheses, the desired compounds are held by covalent bond to the solid-phase. Therefore, the excess reaction reagents can easily be removed by washing. A variety of compounds can be synthesized quickly upon determination of their synthetic routes. Furthermore, they have the advantage of being capable of automatic synthesis. Currently, the reactions which can be utilized in the solid-phase syntheses are limited, however, other potentially utilizable reactions are vigorously being explored.
In the other synthesis of libraries, the liquid-phase reactions are carried out utilizing conventional organic synthetic reactions. Some developments have been reported and future developments are being anticipated.
We have put on the market various kinds of resins which have widely been utilized through the solid-phase synthetic technique and useful diphenylphosphino polystyrene resin for liquid-phase Mitsunobu reaction. Any of these resins are easy to use in meshes, swelling volume and functional content. For the polymer-supported reagent used for liquid-phase synthesis, please refer to "Polymer-Supported Reagents", and for a group of building blocks intended for the preparation of the combinatorial libraries, please refer to "Chemicals by Class".

Resins

Linkers

TNBS & Chloranil Test Kit

Detection of Amines for Primary Amines (for Detection of Free Amine on the Resins)

Detection of Amines for Primary & Secondary Amines (for Detection of Free Amine on the Resins)

Resins

P1719	C1679	H0986
H0987	B2368	B2172
D2765	D2766	A1543
A2047	C1642	C1643
C1744	C1745	C1746
C1747	C1750	C1751
B2370	B2371	B2372
P1379	P1432	S0544
T1889

P1719	(Polystyrylmethyl)trimethylammonium Cyanoborohydride cross-linked with 10% DVB (30-50mesh) (2.6-3.0mmol/g)
C1679	2-Chlorotrityl Chloride Resin cross-linked with 1% DVB (200-400mesh) (1.0-1.8mmol/g)
H0986	4-(Hydroxymethyl)phenoxymethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (0.5-1.0mmol/g)
H0987	4-(Hydroxymethyl)phenoxymethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (1.0-2.0mmol/g)
B2368	4-Benzyloxytrityl Alcohol Resin cross-linked with 1% DVB (200-400mesh) (1.4-1.6mmol/g)
B2172	4-Bromo Polystyrene Resin cross-linked with 2% DVB (200-400mesh) (2.6-2.8mmol/g)
D2765	4-Diphenylphosphino Polystyrene Resin cross-linked with 2% DVB (200-400mesh) (1.0-2.0mmol/g)
D2766	4-Diphenylphosphinomethyl Polystyrene Resin cross-linked with 2% DVB (200-400mesh) (0.5-1.0mmol/g)
A1543	Aminomethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (0.5-0.7mmol/g)
A2047	Aminomethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (2.4-3.0mmol/g)
C1642	Chloromethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (0.8-1.3mmol/g)
C1643	Chloromethyl Polystyrene Resin cross-linked with 1% DVB (200-400mesh) (1.6-1.8mmol/g)
C1744	Chloromethyl Polystyrene Resin cross-linked with 1% DVB (100-200mesh) (0.8-1.2mmol/g)
C1745	Chloromethyl Polystyrene Resin cross-linked with 2% DVB (200-400mesh) (2.0-2.5mmol/g)
C1746	Chloromethyl Polystyrene Resin cross-linked with 2% DVB (200-400mesh) (0.8-1.2mmol/g)
C1747	Chloromethyl Polystyrene Resin cross-linked with 2% DVB (100-200mesh) (2.0-2.5mmol/g)
C1750	Chloromethyl Polystyrene Resin cross-linked with 1% DVB (100-200mesh) (2.0-2.5mmol/g)
C1751	Chloromethyl Polystyrene Resin cross-linked with 2% DVB (100-200mesh) (0.8-1.2mmol/g)
B2370	N-(4-Benzyloxytrityl)-N'-(2-nitrobenzenesulfonyl)-1,2-diaminoethane Resin cross-linked with 1% DVB (200-400mesh) (0.9-1.1mmol/g)
B2371	N-(4-Benzyloxytrityl)-N'-(2-nitrobenzenesulfonyl)-1,3-diaminopropane Resin cross-linked with 1% DVB (200-400mesh) (0.9-1.1mmol/g)
B2372	N-(4-Benzyloxytrityl)-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane Resin cross-linked with 1% DVB (200-400mesh) (0.9-1.1mmol/g)
P1379	Polystyrene Resin cross-linked with 1% DVB (200-400mesh)
P1432	Polystyrene Resin cross-linked with 1% DVB (100-200mesh)
S0544	Sulfonic Acid Polystyrene Resin cross-linked with 15% DVB (70-90mesh) (2.6-3.0mmol/g)
T1889	Trityl Chloride Resin cross-linked with 1% DVB (200-400mesh) (1.0-1.8mmol/g)

Linkers

D2707	H1049	B2322
H0961	H0769

D2707	2,4-Dimethoxy-4'-hydroxybenzophenone
H1049	2-[4-(Hydroxymethyl)-2-nitrophenoxy]acetic Acid Methyl Ester
B2322	2-[4-(tert-Butyldimethylsilyloxymethyl)-2-nitrophenoxy]acetic Acid
H0961	4-(Hydroxymethyl)phenoxyacetic Acid
H0769	4-Hydroxymethylbenzoic Acid

TNBS & Chloranil Test Kit

To conduct the solid phase synthesis, as simple methods TNBS and Chloranil Test are used to detect free amino group on the resin after reaction. Using TNBS Test, the primary amino group can be detected, while Chloranil Test can detect the presence of both primary and secondary amino groups. This method is much safe and simple detection method of free amino group compared to Kaiser Test which requires toxic substance, potassium cyanide fall under the Poisonous and Deleterious Substances Control Law in Japan.

Detection of Amines for Primary Amines (for Detection of Free Amine on the Resins)

D2937

P1447

D2937	N,N-Diisopropylethylamine (ca. 10% in N,N-Dimethylformamide) [for Detection of Primary Amines]
P1447	Picrylsulfonic Acid (ca. 1% in N,N-Dimethylformamide) [for Detection of Primary Amines]
T2024	TNBS Test Kit 2,4,6-Trinitrobenzenesulfonic Acid (ca. 1% in DMF) 10ml*1 / N,N-Diisopropylethylamine (ca. 10% in DMF) 10ml*1 [for Detection of Primary Amines]

Detection of Amines for Primary & Secondary Amines (for Detection of Free Amine on the Resins)

C1770

C1770	Chloranil (ca. 2% in N,N-Dimethylformamide) [for Detection of Primary and Secondary Amines]
C1771	Chloranil Test Kit Chloranil (ca. 2% in DMF) 10ml*1 / Acetaldehyde (ca. 2% in DMF) 10ml*1 [for Detection of Primary and Secondary Amines]