In organic synthesis effective use of protecting groups is very important to a synthetic strategy. A useful protecting group must have the following properties:
- the protective agent must selectively react with the functional group that requires protection.
- the protective group must be introduced in high yields, without side reactions.
- the protected functional groups should be stable against a variety of reactions.
- the protective group should be capable of being selectively deprotected under specific conditions that are not adverse to the integrity of the protected compound.
A list encompasses a wide range of protective agents, from those that provide conventional protecting groups (TMS, Boc, trityl amongst others) to a new special protective agent, 1,2-bis(chlorodimethylsilyl)ethane which reacts only with aliphatic primary amines to generate azadisilacyclopentane derivatives.
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