Protection & Derivatization

In organic synthesis effective use of protecting groups is very important to a synthetic strategy. A useful protecting group must have the following properties:
  - the protective agent must selectively react with the functional group that requires protection.
 - the protective group must be introduced in high yields, without side reactions.
 - the protected functional groups should be stable against a variety of reactions.
 - the protective group should be capable of being selectively deprotected under specific conditions that are not adverse to the integrity of the protected compound.
A list encompasses a wide range of protective agents, from those that provide conventional protecting groups (TMS, Boc, trityl amongst others) to a new special protective agent, 1,2-bis(chlorodimethylsilyl)ethane which reacts only with aliphatic primary amines to generate azadisilacyclopentane derivatives.

M0681 M0681 P1378 P1378 B1128 B1128
B1688 B1688 B1699 B1699 B1773 B1773
B1151 B1151 D1608 D1608 D2334 D2334
T1410 T1410 B1043 B1043 T0670 T0670
M1199 M1199 B1969 B1969 C0795 C0795
D1463 D1463 C1339 C1339 B0988 B0988
T2544 T2544 B1089 B1089 D2504 D2504
M0071 M0071 M0680 M0680 N0516 N0516
N0363 N0363 D0555 D0555 T1535 T1535
M1004 M1004 T1526 T1526 T1071 T1071
D1612 D1612 D2915 D2915 M0441 M0441
M1006 M1006 M0802 M0802 M0790 M0790
N0507 N0507 N0181 N0181 C1400 C1400
T1573 T1573 B1702 B1702 F0197 F0197
B1483 B1483 B2817 B2817 B3021 B3021
C0176 C0176 B2334 B2334 C1591 C1591
C1574 C1574 C1573 C1573 T0589 T0589
C0306 C0306 D1547 D1547 D2469 D2469
P1277 P1277 D2461 D2461 C1600 C1600
P1281 P1281 D2262 D2262 D0695 D0695
D2159 D2159 C1415 C1415 E0471 E0471
E0478 E0478 E0479 E0479 I0303 I0303
M0979 M0979 B1906 B1906 T1277 T1277
C0683 C0683 M1077 M1077 B0916 B0916
T1485 T1485 T0272 T0272 D1044 D1044
B1315 B1315 T0872 T0872 B1436 B1436
B1496 B1496 B0995 B0995 B2697 B2697
T1525 T1525 B1223 B1223 B1663 B1663
T1468 T1468 T1689 T1689 T1078 T1078
T1588 T1588 D2390 D2390 T0871 T0871
T1237 T1237 T0512 T0512 C0308 C0308
M0681 (2-Methoxyethoxymethyl)triethylammonium Chloride
P1378 (Phenylthio)trimethylsilane
B1128 1,2-Benzenedisulfonyl Dichloride
B1688 1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines]
B1699 1,2-Bis(dimethylsilyl)benzene
B1773 1,2-Bis[(dimethylamino)dimethylsilyl]ethane [Protecting Reagent for Aromatic Primary Amines]
B1151 1,3-Benzodithiolylium Tetrafluoroborate [Hydroxyl-Protecting Agent]
D1608 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
D2334 1,3-Dichloro-1,1,3,3-tetramethyldisiloxane
T1410 1-(2,4,6-Triisopropylbenzenesulfonyl)imidazole
B1043 1-(tert-Butyldimethylsilyl)imidazole [tert-Butyldimethylsilylating Agent]
T0670 1-(Trifluoroacetyl)imidazole
M1199 1-Methoxy-1-trimethylsilyloxypropene
B1969 1-tert-Butoxycarbonyl-1,2,4-triazole
C0795 2,2,2-Trichloroethyl Chloroformate
D1463 2,4-Dinitrophenylsulfenyl Chloride
C1339 2-(Chloromethoxy)ethyltrimethylsilane (stabilized with Diisopropylethylamine)
B0988 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
T2544 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate
B1089 2-Boc-thio-4,6-dimethylpyrimidine [Boc Agent for Peptides Synthesis]
D2504 2-Chlorophenyldiphenylmethyl Chloride
M0071 2-Mesitylenesulfonyl Chloride
M0680 2-Methoxyethoxymethyl Chloride
N0516 2-Nitro-5-thiocyanatobenzoic Acid
N0363 2-Nitrophenylsulfenyl Chloride [N-Protecting Agent for Peptides Research]
D0555 3,4-Dihydro-2H-pyran
T1535 3-Trimethylsilyl-2-oxazolidinone [Trimethylsilylating Reagent]
M1004 4'-Methoxyphenacyl Bromide
T1526 4,4',4''-Tris(4,5-dichlorophthalimido)trityl Bromide [Protecting Reagent for Primary Alcohol]
T1071 4,4',4''-Tris(benzoyloxy)trityl Bromide [Hydroxyl Protecting Agent]
D1612 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent]
D2915 4-(Dimethylamino)-1-(triphenylmethyl)pyridinium Chloride (contains 5% Dichloromethane at maximum)
M0441 4-(Methylthio)phenol
M1006 4-Methoxy-2-nitrobenzenesulfonyl Chloride
M0802 4-Methoxybenzenesulfonyl Chloride
M0790 4-Methoxytrityl Chloride [Hydroxyl Protecting Agent]
N0507 4-Nitrobenzenesulfonyl Fluoride
N0181 4-Nitrobenzyl Bromide
C1400 4-Nitrophenyl Chloroformate
T1573 4-Trimethylsilyloxy-3-penten-2-one
B1702 9-Bromo-9-phenylfluorene
F0197 9-Fluorenylmethyl Chloroformate [N-Protecting Agent for Peptides Research]
B1483 Benzyl 2,2,2-Trichloroacetimidate
B2817 Benzyl 2-Bromoethyl Ether
B3021 Benzyl Chloroformate
C0176 Benzyl Chloroformate (30-35% in Toluene)
B2334 Benzylchlorodimethylsilane
C1591 Carbonic Acid Benzyl 4-Nitrophenyl Ester
C1574 Carbonic Acid tert-Butyl 2,4,5-Trichlorophenyl Ester
C1573 Carbonic Acid tert-Butyl Phthalimido Ester
T0589 Chlorotriethylsilane
C0306 Chlorotrimethylsilane
D1547 Di-tert-butyl Pyrocarbonate [Boc-reagent for Amino Acid]
D2469 Di-tert-butyldichlorosilane
P1277 Diallyl Pyrocarbonate
D2461 Dibenzosuberyl Chloride
C1600 Dibenzyl Carbonate
P1281 Dibenzyl Pyrocarbonate
D2262 Diethylisopropylsilyl Chloride
D0695 Dimethylcarbamoyl Chloride
D2159 Dimethylthiophosphinic Chloride
C1415 Diphenylphosphinic Chloride
E0471 Ethylene Di(thiotosylate) [Protecting Reagent for Active Methylene]
E0478 Ethylenedioxybis(trimethylsilane) [Protecting Reagent for Aldehydes and Ketones]
E0479 Ethylenedithiobis(trimethylsilane) [Protecting Reagent for Aldehydes and Ketones]
I0303 Isopropenyl Methyl Ether
M0979 Methoxycarbonylsulfenyl Chloride
B1906 N,O-Bis(tert-butyldimethylsilyl)acetamide [tert-Butyldimethylsilylating Agent]
T1277 N-(Trimethylsilyl)morpholine
C0683 N-Ethoxycarbonylphthalimide [for Peptide synthesis]
M1077 N-Methyl-N,O-bis(trimethylsilyl)hydroxylamine
B0916 N-tert-Butoxycarbonylimidazole
T1485 p-Toluenesulfonic Anhydride
T0272 p-Toluenesulfonyl Chloride
D1044 Pentachlorophenyl Dichloroacetate [for Peptide synthesis]
B1315 Phenacyl 4-(Bromomethyl)phenylacetate
T0872 S-Ethyl Trifluorothioacetate [Trifluoroacetylating Agent for Peptides Research]
B1436 tert-Butoxydiphenylchlorosilane (stabilized with CaCO3)
B1496 tert-Butyl 2,2,2-Trichloroacetimidate
B0995 tert-Butyldimethylchlorosilane [tert-Butyldimethylsilylating Agent]
B2697 tert-Butyldimethylsilyl N-Phenylbenzimidate
T1525 tert-Butyldimethylsilyl Trifluoromethanesulfonate
B1223 tert-Butyldiphenylchlorosilane
B1663 tert-Butylmethoxyphenylsilyl Bromide
T1468 Trifluoromethanesulfonic Acid Diethylisopropylsilyl Ester
T1689 Trifluoromethanesulfonic Acid Triethylsilyl Ester
T1078 Triisopropylsilyl Chloride
T1588 Triisopropylsilyl Trifluoromethanesulfonate
D2390 Trimethylene Di(thiotosylate) [Protecting Reagent for Active Methylene]
T0871 Trimethylsilyl Trifluoromethanesulfonate [Trimethylsilylating Agent]
T1237 Triphenylmethanesulfenyl Chloride
T0512 Triphenylmethyl Bromide
C0308 Triphenylmethyl Chloride


kdjoad0000003vyc