Fluorinating Reagents, Building Blocks
& Fluorinated Bioactive Compounds

Introduction of fluorine into a certain position of bioactive compound such as a pharmaceutical and an agricultural chemical may remarkably reduce the toxicity of the compound, or improve the efficiency of medicine. This is due to the mimic and blocking effect characterized by fluorine. Many compounds, such as 5-fluorouracil, have been reported as success case.
Attempts to efficiently synthesize fluorine-containing compounds are performed in many fields. Methods to introduce fluorine into a certain position through the use of fluorinating agents or the use of fluorine-containing building blocks have been reported.

Recently, triethyl 2-fluoro-2-phosphonoacetate has increasingly been utilized as a useful bifunctional fluorine-containing intermediate. This compound is very useful in the generation of physiologically active compounds because it can generate α-fluoro-α,β-unsaturated ester from the reaction with carbonyl compounds in the presence of a base. A subsequent reduction of the above ester leads to the corresponding aldehyde or alcohol. As examples, vitamin A derivatives1), pheromone of insect origin, synthesis of Pyrethroide having insecticidal efficacy, etc., can be given.

Electrophilic Fluorinating Reagents

Nucleophilic Fluorinating Reagents

Fits Reagents

Fluorinated Building Blocks

Fluorinated Bioactive Compounds

Electrophilic Fluorinating Reagents

F0342 F0342 D3812 D3812 F0335 F0335
F0344 F0344 F0358 F0358 F0334 F0334
F0343 F0343 F0327 F0327 F0346 F0346
F0328 F0328
F0342 2,6-Dichloro-1-fluoropyridinium Trifluoromethanesulfonate [Fluorinating Reagent]
D3812 1,1'-Difluoro-2,2'-bipyridinium Bis(tetrafluoroborate)
F0335 N-Fluorobenzenesulfonimide [Fluorinating Reagent]
F0344 1-Fluoro-2,6-dichloropyridinium Tetrafluoroborate [Fluorinating Reagent]
F0358 N-Fluoro-N'-(chloromethyl)triethylenediamine Bis(tetrafluoroborate)
F0334 1-Fluoropyridinium Pyridine Heptafluorodiborate [Fluorinating Reagent]
F0343 1-Fluoropyridinium Tetrafluoroborate [Fluorinating Reagent]
F0327 1-Fluoropyridinium Trifluoromethanesulfonate [Fluorinating Reagent]
F0346 1-Fluoro-2,4,6-trimethylpyridinium Tetrafluoroborate [Fluorinating Reagent]
F0328 1-Fluoro-2,4,6-trimethylpyridinium Trifluoromethanesulfonate [Fluorinating Reagent]
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Nucleophilic Fluorinating Reagents

B2440 B2440 B3664 B3664 D3146 D3146
D1868 D1868 D2831 D2831 H0598 H0598
M1573 M1573 T1295 T1295 T1909 T1909
T1592 T1592 T1635 T1635 T1037 T1037
T1125 T1125 T1338 T1338 T1339 T1339
T2027 T2027 T2026 T2026 T2754 T2754
T2022 T2022
B2440 Bis(2-methoxyethyl)aminosulfur Trifluoride
B3664 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride
D3146 N,N-Diethyl-alpha,alpha-difluoro-3-methylbenzylamine
D1868 (Diethylamino)sulfur Trifluoride [Fluorinating Reagent]
D2831 2,2-Difluoro-1,3-dimethylimidazolidine
H0598 Ishikawa's Reagent [Fluorinating Reagent]
M1573 Morpholinosulfur Trifluoride
T1295 Tetrabutylammonium Bifluoride
T1909 Tetrabutylammonium Difluorotriphenylsilicate
T1592 Tetrabutylammonium Difluorotriphenylstannate
T1635 Tetrabutylammonium Dihydrogen Trifluoride
T1037 Tetrabutylammonium Fluoride Hydrate [for Catalyst of acylation, silylation and cleavage of silyl ether]
T1125 Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran) [for Catalyst of acylation, silylation and cleavage of Silyl Ether]
T1338 Tetrabutylammonium Fluoride (ca. 1mol/L in Tetrahydrofuran)
T1339 Tetrabutylammonium Fluoride (70-75% in Water)
T2027 Tetraethylammonium Fluoride Tetrahydrofluoride
T2026 Tetraethylammonium Fluoride Trihydrofluoride
T2754 Tetramethylammonium Fluoride Tetrahydrate
T2022 Triethylamine Trihydrofluoride
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Fits Reagents

P1080 P1080 P1659 P1659 P1081 P1081
P1082 P1082
P1080 (Perfluorohexyl)phenyliodonium Trifluoromethanesulfonate
P1659 (Perfluoroisopropyl)phenyliodonium Trifluoromethanesulfonate
P1081 (Perfluoro-n-octyl)phenyliodonium Trifluoromethanesulfonate
P1082 (Perfluoropropyl)phenyliodonium Trifluoromethanesulfonate
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Fluorinated Building Blocks

Aliphatic Compounds

A2344 A2344 A2400 A2400 B3683 B3683
B2723 B2723 B3681 B3681 B3781 B3781
B1830 B1830 B1855 B1855 B2945 B2945
B3743 B3743 B3498 B3498 B2133 B2133
B2722 B2722 B3782 B3782 B3783 B3783
B3797 B3797 B3688 B3688 B3808 B3808
B1801 B1801 C0990 C0990 C1503 C1503
C2514 C2514 C2381 C2381 C1638 C1638
C2527 C2527 C2098 C2098 C2118 C2118
C2308 C2308 C2359 C2359 C2360 C2360
C2474 C2474 C2482 C2482 C2483 C2483
C2484 C2484 C2200 C2200 C2476 C2476
C2456 C2456 D4046 D4046 D3972 D3972
F0283 F0283 D2523 D2523 D1423 D1423
D2941 D2941 D3342 D3342 D4121 D4121
D4051 D4051 D1629 D1629 D1838 D1838
D2818 D2818 D1847 D1847 D1996 D1996
D3343 D3343 D3373 D3373 D4034 D4034
D2343 D2343 D4115 D4115 D4128 D4128
D3985 D3985 D2338 D2338 D2351 D2351
D3497 D3497 D4042 D4042 B1463 B1463
B1673 B1673 C1458 C1458 C1467 C1467
D2530 D2530 D2498 D2498 D2782 D2782
E0547 E0547 F0030 F0030 E0861 E0861
F0203 F0203 F0395 F0395 E0663 E0663
T0432 T0432 T0810 T0810 F0665 F0665
F0396 F0396 F0405 F0405 F0557 F0557
F0202 F0202 F0790 F0790 F0393 F0393
F0422 F0422 F0722 F0722 F0244 F0244
F0248 F0248 F0723 F0723 F0725 F0725
F0704 F0704 F0668 F0668 F0706 F0706
F0786 F0786 F0796 F0796 F0660 F0660
F0720 F0720 F0730 F0730 F0662 F0662
F0680 F0680 F0681 F0681 F0671 F0671
F0746 F0746 F0792 F0792 F0805 F0805
F0806 F0806 F0748 F0748 F0690 F0690
F0666 F0666 F0683 F0683 F0697 F0697
F0712 F0712 F0341 F0341 F0212 F0212
F0695 F0695 F0777 F0777 F0789 F0789
F0703 F0703 F0391 F0391 F0399 F0399
F0670 F0670 F0694 F0694 F0737 F0737
F0797 F0797 F0661 F0661 F0696 F0696
F0655 F0655 A1429 A1429 F0216 F0216
F0794 F0794 F0776 F0776 F0778 F0778
F0711 F0711 F0673 F0673 F0651 F0651
F0779 F0779 F0741 F0741 F0808 F0808
F0774 F0774 F0760 F0760 F0701 F0701
F0762 F0762 F0732 F0732 F0754 F0754
F0780 F0780 F0788 F0788 F0692 F0692
F0518 F0518 T0436 T0436 C1586 C1586
F0311 F0311 T1245 T1245 P1894 P1894
C0991 C0991 T2732 T2732 T1883 T1883
T1032 T1032 F0340 F0340 T0791 T0791
T0433 T0433 T2733 T2733 T2758 T2758
T2793 T2793 T0435 T0435 M1193 M1193
T1516 T1516 T1604 T1604 T2638 T2638
T1512 T1512 T2783 T2783 T2547 T2547
A2344 2-Amino-6-fluorobenzonitrile
A2400 2-Amino-4-fluorophenol
B3683 2-Benzyloxy-5-fluorophenylboronic Acid (contains varying amounts of Anhydride)
B2723 2-Bromo-4-chloro-6-fluoroaniline
B3681 2-Bromo-6-chloro-4-fluoroaniline
B3781 5-Bromo-2,2-difluoro-1,3-benzodioxole
B1830 2-Bromo-4-fluoroanisole
B1855 4-Bromo-2-fluoroanisole
B2945 3-Bromo-5-fluoroanisole
B3743 4-Bromo-3-fluoroanisole
B3498 2-Bromo-4-fluorobenzaldehyde
B2133 3-Bromo-4-fluorobenzoic Acid
B2722 2-Bromo-5-fluorobenzoic Acid
B3782 3-Bromo-5-fluorobenzoic Acid
B3783 4-Bromo-3-fluorobenzotrifluoride
B3797 1-Bromo-4-fluoronaphthalene
B3688 4-Bromo-3-fluorophenol
B3808 1-Bromo-3-fluoro-4-(trifluoromethoxy)benzene
B1801 2-Bromo-3,3,3-trifluoro-1-propene (stabilized with Copper chip)
C0990 Chlorodifluoroacetic Acid
C1503 Chlorodifluoroacetic Anhydride
C2514 1-Chloro-3,5-difluorobenzene
C2381 2-Chloro-5-fluorobenzaldehyde
C1638 2-Chloro-6-fluorobenzyl Alcohol
C2527 2-Chloro-4-fluorobenzyl Alcohol
C2098 2-Chloro-4-fluorobenzyl Bromide
C2118 3-Chloro-2-fluorobenzyl Bromide
C2308 2-Chloro-6-fluorobenzyl Bromide
C2359 2-Chloro-5-fluorobenzyl Bromide
C2360 5-Chloro-2-fluorobenzyl Bromide
C2474 3-Chloro-5-fluorobenzyl Bromide
C2482 3-Chloro-4-fluorobenzyl Bromide
C2483 4-Chloro-2-fluorobenzyl Bromide
C2484 4-Chloro-3-fluorobenzyl Bromide
C2200 4-Chloro-2-fluorocinnamic Acid
C2476 4-Chloro-3-fluorophenol
C2456 4-Cyano-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
D4046 1,3-Dichloro-5-fluorobenzene
D3972 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile
F0283 Diethyl Fluoromalonate
D2523 Difluoroacetaldehyde Ethyl Hemiacetal
D1423 Difluoroacetic Acid
D2941 3,4-Difluorobenzenesulfonyl Chloride
D3342 2,4-Difluorobenzenethiol
D4121 3,4-Difluorobenzenethiol
D4051 2,2-Difluoro-1,3-benzodioxole
D1629 2,6-Difluorobenzoic Acid
D1838 2,4-Difluorobenzyl Alcohol
D2818 2,5-Difluorobenzyl Alcohol
D1847 2,6-Difluorobenzylamine
D1996 2,4-Difluorobenzylamine
D3343 3,5-Difluorobenzylamine
D3373 3,4-Difluorobenzylamine
D4034 2,5-Difluorobenzylamine
D2343 2,4-Difluorocinnamic Acid
D4115 trans-2,6-Difluorocinnamic Acid
D4128 2,2-Difluoroethanol
D3985 2,6-Difluoro-4-hydroxybenzoic Acid
D2338 2,6-Difluorotoluene
D2351 2,4-Difluorotoluene
D3497 2,3-Difluorotoluene
D4042 2,5-Difluorotoluene
B1463 Ethyl Bromodifluoroacetate
B1673 Ethyl Bromofluoroacetate
C1458 Ethyl Chlorodifluoroacetate
C1467 Ethyl Chlorofluoroacetate
D2530 Ethyl Dibromofluoroacetate
D2498 Ethyl Difluoroacetate
D2782 Ethyl 3-(Dimethylamino)-3-ethoxy-2,2-difluoropropionate
E0547 Ethyl 3-Ethoxy-2,2-difluoro-3-hydroxypropionate
F0030 Ethyl Fluoroacetate
E0861 Ethyl 3-Fluorobenzoate
F0203 Ethyl 4-Fluorobenzoate
F0395 Ethyl 2-Fluorobenzoate
E0663 Ethyl 2-Fluoropropionate
T0432 Ethyl Trifluoroacetate
T0810 Ethyl 4,4,4-Trifluoroacetoacetate
F0665 Fluoroacetonitrile
F0396 5-Fluoroanthranilic Acid
F0405 4-Fluoroanthranilic Acid
F0557 2-Fluorobenzenesulfonamide
F0202 4-Fluorobenzenesulfonyl Chloride
F0790 3-Fluorobenzenesulfonyl Chloride
F0393 4-Fluorobenzenethiol
F0422 3-Fluorobenzenethiol
F0722 4-Fluorocinnamaldehyde
F0244 4-Fluorocinnamic Acid
F0248 2-Fluorocinnamic Acid
F0723 4'-Fluoro-2'-hydroxyacetophenone
F0725 3-Fluoro-4-hydroxybenzaldehyde
F0704 4-Fluoro-4'-hydroxybiphenyl
F0668 6-Fluoro-1-indanone
F0706 4-Fluoro-2-iodoaniline
F0786 2-Fluoro-5-iodobenzoic Acid
F0796 2-Fluoro-6-iodobenzoic Acid
F0660 2-Fluoro-6-iodobenzonitrile
F0720 2-Fluoro-4-iodotoluene
F0730 2-Fluoro-DL-mandelic Acid
F0662 2'-Fluoro-4'-methoxyacetophenone
F0680 4-Fluoro-2-methoxybenzoic Acid
F0681 4-Fluoro-3-methoxybenzoic Acid
F0671 3-Fluoro-4-methoxybenzonitrile
F0746 5-Fluoro-2-methylbenzaldehyde
F0792 3-Fluoro-4-methylbenzaldehyde
F0805 3-Fluoro-N-methylbenzylamine
F0806 4-Fluoro-N-methylbenzylamine
F0748 5-Fluoro-2-methylbenzyl Bromide
F0690 2-Fluoro-5-methyldiphenylamine
F0666 4-Fluoro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
F0683 2-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride)
F0697 4-Fluoro-3-methylphenylboronic Acid (contains varying amounts of Anhydride)
F0712 3-Fluoro-4-methylphenylboronic Acid (contains varying amounts of Anhydride)
F0341 Fluoromethyl Phenyl Sulfone
F0212 1-Fluoronaphthalene
F0695 6-Fluoronicotinic Acid
F0777 4'-Fluoro-3'-nitroacetophenone
F0789 5-Fluoro-2-nitroaniline
F0703 5-Fluoro-2-nitroanisole
F0391 2-Fluoro-5-nitrobenzoic Acid
F0399 4-Fluoro-3-nitrobenzoic Acid
F0670 3-Fluoro-4-nitrobenzoic Acid
F0694 5-Fluoro-2-nitrobenzoic Acid
F0737 4-Fluoro-2-nitrobenzoic Acid
F0797 2-Fluoro-4-nitrobenzoic Acid
F0661 2-Fluoro-3-nitrotoluene
F0696 2-Fluoro-6-nitrotoluene
F0655 4-Fluorophenetole
A1429 4-Fluorophenyl Acetate
F0216 3-Fluorophenylacetic Acid
F0794 4-Fluoro-1,3-phenylenediamine
F0776 2-(3-Fluorophenyl)ethanol
F0778 2-(2-Fluorophenyl)ethanol
F0711 2-Fluorophenyl Isothiocyanate
F0673 4-Fluorophenylmagnesium Bromide (ca. 18% in Tetrahydrofuran, ca. 0.9mol/L)
F0651 4-Fluorophenyl Methyl Sulfone
F0779 3-(3-Fluorophenyl)propionic Acid
F0741 4-Fluororesorcinol
F0808 4'-Fluoro-3'-(trifluoromethyl)acetophenone
F0774 3-Fluoro-5-(trifluoromethyl)benzaldehyde
F0760 4-Fluoro-3-(trifluoromethyl)benzoic Acid
F0701 2-Fluoro-6-(trifluoromethyl)benzonitrile
F0762 2-Fluoro-3-(trifluoromethyl)benzoyl Chloride
F0732 2-Fluoro-6-(trifluoromethyl)benzyl Bromide
F0754 4-Fluoro-3-(trifluoromethyl)phenol
F0780 2-Fluoro-5-(trifluoromethyl)phenol
F0788 2-Fluoro-5-(trifluoromethyl)phenylboronic Acid (contains varying amounts of Anhydride)
F0692 Fluorotrimethylsilylketene Ethyl Trimethylsilyl Acetal (mixture of isomers)
F0518 (1-Fluorovinyl)methyldiphenylsilane
T0436 3-Hydroxybenzotrifluoride
C1586 Methyl Chlorodifluoroacetate
F0311 Methyl Fluorosulfonyldifluoroacetate
T1245 Methyl 4,4,4-Trifluoroacetoacetate
P1894 Pentafluorophenyl Trifluoroacetate
C0991 Sodium Chlorodifluoroacetate
T2732 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol
T1883 2,3,4,5-Tetrafluorobenzyl Alcohol
T1032 1,1,1-Trichloro-2,2,2-trifluoroethane
F0340 Triethyl 2-Fluoro-2-phosphonoacetate
T0791 Trifluoroacetaldehyde Ethyl Hemiacetal (contains ca. 10% Ethanol)
T0433 Trifluoroacetic Anhydride
T2733 2',4',6'-Trifluoroacetophenone
T2758 2',4',5'-Trifluoroacetophenone
T2793 2,4,5-Trifluorobenzyl Alcohol
T0435 2,2,2-Trifluoroethanol
M1193 2,2,2-Trifluoroethyl Methanesulfonate
T1516 2,2,2-Trifluoroethyl p-Toluenesulfonate
T1604 2,2,2-Trifluoroethyl Trifluoromethanesulfonate
T2638 2,2,2-Trifluoro-N-(4-methoxyphenyl)acetimidoyl Chloride
T1512 2-(Trifluoromethyl)acrylic Acid
T2783 2,3,4-Trifluoro-6-nitroaniline
T2547 2,2,2-Trifluoro-N-phenylacetimidoyl Chloride
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Heterocyclic Compounds

A1993 A1993 A2125 A2125 A1664 A1664
A2384 A2384 A1546 A1546 B2705 B2705
B2799 B2799 B3244 B3244 B3685 B3685
B3177 B3177 B3178 B3178 C2113 C2113
C2221 C2221 C2270 C2270 C2303 C2303
C2515 C2515 C1549 C1549 C1666 C1666
C2456 C2456 D3614 D3614 D3642 D3642
D3615 D3615 D2610 D2610 D3317 D3317
D3374 D3374 D2057 D2057 D1741 D1741
E0684 E0684 F0647 F0647 F0656 F0656
F0180 F0180 F0702 F0702 F0534 F0534
F0352 F0352 F0369 F0369 F0555 F0555
F0556 F0556 F0716 F0716 F0523 F0523
F0733 F0733 F0551 F0551 F0589 F0589
F0693 F0693 F0547 F0547 F0316 F0316
F0420 F0420 F0520 F0520 F0533 F0533
F0579 F0579 F0581 F0581 F0300 F0300
F0519 F0519 F0575 F0575 F0738 F0738
F0382 F0382 F0699 F0699 F0207 F0207
F0217 F0217 F0628 F0628 F0038 F0038
T1778 T1778 T2342 T2342 T2061 T2061
A1993 2-Amino-6-fluorobenzothiazole
A2125 4-Amino-5-fluoro-2-methoxypyrimidine
A1664 2-Amino-5-fluoropyridine
A2384 5-Amino-2-fluoropyridine
A1546 4-Amino-2,3,5,6-tetrafluoropyridine
B2705 5-Bromo-2-fluoropyridine
B2799 2-Bromo-5-fluoropyridine
B3244 3-Bromo-5-fluoropyridine
B3685 5-Bromo-2-fluoropyrimidine
B3177 (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
B3178 (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid
C2113 5-Chloro-2,3-difluoropyridine
C2221 6-Chloro-2-fluoropurine
C2270 2-Chloro-5-fluoropyridine
C2303 5-Chloro-2-fluoropyridine
C2515 3-Chloro-2-fluoropyridine
C1549 3-Chloro-2,4,5,6-tetrafluoropyridine
C1666 5-Chloro-2,4,6-trifluoropyrimidine
C2456 4-Cyano-3-fluorophenylboronic Acid (contains varying amounts of Anhydride)
D3614 2'-Deoxy-2'-fluorocytidine Hydrate
D3642 2'-Deoxy-5-fluorocytidine
D3615 2'-Deoxy-2'-fluorouridine
D2610 2,6-Dichloro-5-fluoronicotinic Acid
D3317 3,5-Dichloro-2-fluoropyridine
D3374 2,4-Dichloro-5-fluoropyrimidine
D2057 3,5-Dichloro-2,4,6-trifluoropyridine
D1741 2,6-Difluoropyridine
E0684 2-Ethoxy-5-fluoro-4-pyrimidinone
F0647 2-Fluoroadenine
F0656 2-Fluoroadenosine
F0180 2-Fluorobenzothiazole
F0702 4-Fluoro-2,1,3-benzoxadiazole
F0534 5-Fluorocytidine
F0352 6-Fluoroindole
F0369 5-Fluoroindole
F0555 7-Fluoroindole
F0556 4-Fluoroindole
F0716 5-Fluoroindole-2-carboxylic Acid
F0523 2-Fluoro-5-iodopyridine
F0733 2-Fluoro-3-iodopyridine
F0551 7-Fluoroisatin
F0589 5-Fluoroisatin
F0693 2-Fluoroisonicotinic Acid
F0547 5-Fluoro-2-methoxy-4-pyrimidinone
F0316 5-Fluoro-2-methylbenzothiazole
F0420 5-Fluoro-2-methylbenzoxazole
F0520 2-Fluoro-6-methylpyridine
F0533 2-Fluoro-3-methylpyridine
F0579 2-Fluoro-4-methylpyridine
F0581 2-Fluoro-5-methylpyridine
F0300 6-Fluoro-2-methylquinoline
F0519 7-Fluoro-2-methylquinoline
F0575 2-Fluoronicotinic Acid
F0738 5-Fluoronicotinic Acid
F0382 5-Fluoroorotic Acid Monohydrate
F0699 5-Fluorooxindole
F0207 3-Fluoropyridine
F0217 2-Fluoropyridine
F0628 4-Fluoropyridine Hydrochloride
F0038 5-Fluoro-8-quinolinol
T1778 2,3,5,6-Tetrafluoropyridine
T2342 3,3,4,4-Tetrafluoropyrrolidine Hydrochloride
T2061 3,5,6-Trifluoro-2-hydroxypyridine
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Fluorinated Bioactive Compounds

B1837 B1837 C2485 C2485 C2227 C2227
C2370 C2370 D2235 D2235 D3579 D3579
D3773 D3773 E0762 E0762 E0786 E0786
F0646 F0646 F0677 F0677 F0657 F0657
F0321 F0321 F0691 F0691 F0635 F0635
F0151 F0151 F0636 F0636 F0371 F0371
F0663 F0663 F0525 F0525 L0193 L0193
L0216 L0216 N0817 N0817 P1897 P1897
P1962 P1962 T2506 T2506 T2308 T2308
T2511 T2511
B1837 Betamethasone
C2485 1-Chloro-2,2,2-trifluoroethyl Difluoromethyl Ether
C2227 Ciprofloxacin Hydrochloride Monohydrate
C2370 Citalopram Hydrobromide
D2235 2'-Deoxy-5-fluorouridine
D3579 5'-Deoxy-5-fluorouridine
D3773 1,1-Dimethyl-3-[3-(trifluoromethyl)phenyl]urea
E0762 Enoxacin Sesquihydrate
E0786 Enrofloxacin
F0646 Fleroxacin
F0677 Fluconazole
F0657 Fluocinolone Acetonide
F0321 5-Fluorocytosine
F0691 Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether
F0635 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil
F0151 5-Fluorouracil
F0636 5-Fluorouridine
F0371 Flurbiprofen
F0663 Flutamide
F0525 Fluticasone Propionate
L0193 Levofloxacin
L0216 Lomefloxacin Hydrochloride
N0817 Norfloxacin
P1897 Paliperidone
P1962 Pazufloxacin Mesylate
T2506 Tosufloxacin p-Toluenesulfonate Hydrate
T2308 Triamcinolone Acetonide
T2511 Trifluorothymidine
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Literature

1) Synthesis of fluorinated retinoic acids and their analogs
R. S. H. Liu, H. Matsumoto, A. E. Asato, M. Denny, Y. Shichida, T. Yoshizawa, F. W. Dahlquist, J. Am. Chem. Soc., 1981, 103, 7195 [DOI]; A. J. Lovey, B. A. Pawson, J. Med. Chem., 1982, 25, 71 [DOI].
2) Triethyl 2-Fluoro-2-phosphonoacetate
M. Kikuchi, T. Onozawa, Yuki Gosei Kagaku Kyokaishi (J. Synth. Org. Chem., Jpn), 1997, 55, 88.

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