Steroids are the collective term for compounds with a structure named a steroid nucleus which is composed of three linked six-membered rings and one fi ve-membered ring. Almost all living organisms such as, animals, plants, insects, and bacteria produce steroids which play important roles together with vitamins in living organisms. Cholesterol, a crucial lipid component of cell membranes, is a typical steroid. Furthermore, some steroids called steroid hormones act as adrenal cortex or sexual hormones.
●Steroid Hormones: Estranes, Androstanes, Pregnanes
Certain kinds of steroids like estrogenes, androstanes and pregnanes can act as hormones, their activities being closely related to their structures (Table 1). Pregnane-type steroids can be classified into glucocorticoids and progestogens based on their bioactivities. Their classification and the typical compounds in each category are illustrated as follows:
Estrogens: Estrogens function as the primary female sex hormone and in combination with synthetic progestogens can be used as oral contraceptives to suppress ovulation. Recently, it is also reported that they are effective for the prevention of osteoporosis, heart attacks and Alzheimer’s disease in women.
Androgens: Testosterone is not only the principal and most well known male sex hormone but is also known to exert anabolic effects. This is also the main reason why some of them have been banned from use as bone density enhancers and muscle-building drugs by several sports organizations. They are also the intermediates of estrogene biosynthetic pathway or rather the precursors of all estrogens.
Progestogens: The only naturally occuring progestogen, i.e., progesterone, exhibits antiovulatory action. Based on its structure, derivatives of 19-nortestosterone were synthesized and can be used as oral contraceptives.
Glucocorticoids: Synthetic glucocorticoids such as dexamethasone and prednisolone find clinical use as anti-inflammatory agents. They are synthetically developed based on the structure of cortisone, a natural glucocorticoid.
WARNING
Some of the steroid hormones may cause serious physiological actions. To avoid inhalation and contacting with skin, wear protective goggles, mask and eyeglasses when handling. Sufficient caution should be taken, when using these compounds, from the opening up to the disposal of the reagents.
●Bile Acids: Cholanes
Cholane type steroids are predominantly found in the bile. Cholic acid and its derivatives exist in bile as the major component as conjugates of glycine and taurine. Since conjugated cholates are amphiphilic, they assist in the digestion and absorption of lipids in small intestine. This characteristic is also exploited also in its use as a surfactant.
●Cholesterol: Cholestanes
Cholesterol possesses a cholestane-type skeleton and in conjugation with fatty acids, it forms the main component of cell membranes in animals and microorganisms. These cholesterol conjugates establish and maintain proper membrane permeability. In addition, it is a precursor of steroids as mentioned above and also exists in its liberated form in organisms.
●Phytosteroids, Steroid Glycosides, Miscellaneous Steroids
Steroids of plant origin have different biosynthetic pathways: they are synthesized from cycloartenol. They possess structural features distinct from animal steroids, for instance, a characteristic alkyl side-chain at C-24. Steroid glycosides and their aglycones are also listed in this section.
Estranes
Androstanes
Pregnanes
Cholanes (Bile Acids)
Cholestanes
Phytosteroids, Steroid Glycosides & Other Steroids
Estranes
E0025
|
E0329
|
E0875
|
E0876
|
E0218
|
E0026
|
E0037
|
M0728
|
| E0025 | beta-Estradiol |
| E0329 | Estradiol Benzoate |
| E0875 | beta-Estradiol 17-Cypionate |
| E0876 | beta-Estradiol 17-Valerate |
| E0218 | Estriol |
| E0026 | Estrone |
| E0037 | Ethynylestradiol |
| M0728 | Mestranol |
Androstanes
A1397
|
M0638
|
| A1397 | Adrenosterone |
| M0638 | DELTA9(11)-Methyltestosterone |
Pregnanes
Progestogen
E0015
|
E0198
|
F0414
|
H0499
|
H0994
|
M1964
|
M1949
|
P0678
|
P0771
|
P0786
|
P0477
|
P0478
|
Glucocorticoids
B1837
|
B3166
|
C1478
|
C0388
|
C1479
|
C0389
|
D3628
|
D3918
|
F0657
|
F0525
|
H0533
|
H0184
|
T2308
|
Cholanes (Bile Acids)
C0750
|
C1578
|
D0042
|
C0315
|
H0521
|
H0869
|
L0089
|
C1412
|
H0529
|
O0267
|
C0325
|
S0596
|
D0043
|
C0316
|
D1820
|
G0207
|
H0870
|
T0808
|
U0068
|
T1567
|
U0030
|
Cholestanes
C0317
|
C1366
|
C0318
|
C1222
|
C0695
|
C0610
|
Phytosteroids, Steroid Glycosides & Other Steroids
Phytosteroids
E0018
|
S0040
|
S0221
|
S0386
|
S0088
|
| E0018 | Ergosterol |
| S0040 | beta-Sitosterol (contains Campesterol) |
| S0221 | beta-Sitosterol Acetate (contains Campesterol Acetate) |
| S0386 | Stigmastanol |
| S0088 | Stigmasterol |
Steroid Glycosides
D0540
|
S0091
|
T0329
|
| D0540 | Digitonin |
| S0091 | g-Strophanthin Octahydrate |
| T0329 | Tomatine [for Cholesterol assay] |
Other Steroids
D0541
|
D1474
|
E0040
|
F0675
|
H0003
|
M1732
|
N0450
|
N0889
|
| D0541 | Digitoxigenin |
| D1474 | Diosgenin |
| E0040 | Ethisterone |
| F0675 | Finasteride |
| H0003 | Hecogenin |
| M1732 | Mifepristone |
| N0450 | Norethisterone Acetate |
| N0889 | (-)-Norgestrel |
Literature
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