| TCI产品编码 : | B3449 | ||||||||||
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| 库存情况 : |
2012年02月09号上午06点的情况 *2012年4月前，中国库存将暂时显示上海仓库和天津仓库的库存总和。 |
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| 纯度 / 分析方法 : | >98.0%(GC) | ||||||||||
| 保存温度 : | Refrigerator | ||||||||||
| 分子式 / 分子量 : | C31H28P2=462.51 | ||||||||||
| CAS编码 : | 71042-55-2 | ||||||||||
| 相关CAS编码 : | |||||||||||
| MDL编码 : | MFCD00085365 | ||||||||||
| 监管条件代码 : | |||||||||||
| 国内危险化学品编码 : | |||||||||||
| mp : | 130 °C |
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| [α]20D : | -49 ° (C=1, CHCl3) |
Asymmetric hydrogenation with rhodium catalyst Typical procedure: (2R,3R)-(-)-Norphos (3.7 mg) and [Rh(cod)Cl]2 (4 mg) were stirred in methanol (5 mL) in a hydrogen atmosphere for 15 min, giving an orange solution. (Z)-2-Benzamido-3-ferrocenylacrylic acid (1)(3.76 g) was dissolved in methanol (20 mL) and the catalytic orange solution was added under nitrogen. Then, the reaction vessel was vented three times with hydrogen. Hydrogenation at 1.1 atm proceeded at room temperature and was stopped after 3.5 d, when the hydrogen uptake was complete. After the hydrogenation, the solvent was evaporated and the residue was treated with 1N NaOH (2.5 mL) for 30 min. The solution was filtered, diluted with water (20 mL), acidified with 1N HCl and extracted with ether. The organic phase was dried over Na2SO4 and concentrated to dryness to give (2S)-2-benzamido-3-ferrocenylpropanic acid (2)(3.4 g, 90 %, 90.5-94.5 % ee) as yellow solid. |
| 相关分类 : |
Synthetic Organic Chemistry
Asymmetric Synthesis
Synthetic Organic Chemistry Phosphines Synthetic Organic Chemistry Ligands Phosphine Ligands |
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